💊 Danavir-R 800 (Darunavir + Ritonavir) Tablets

📌 What Is Danavir-R 800?

• Danavir-R 800 is a fixed-dose antiretroviral medication used in the management of HIV-1 infection.

• It contains:

  • Darunavir 800 mg – a protease inhibitor (PI)

  • Ritonavir (as a booster) – a pharmacokinetic enhancer that increases Darunavir’s effectiveness

• Prescribed in combination with other antiretroviral agents as part of Highly Active Antiretroviral Therapy (HAART).

• Helps reduce viral load, increase CD4+ T-cell count, and prevent disease progression.

💊 Pharmacological Action of Each Ingredient

1️⃣ Darunavir

• Class: Protease Inhibitor (PI)

• Mechanism of Action:

  • Inhibits the HIV-1 protease enzyme, which is essential for cleaving viral polyproteins into mature functional proteins.

  • Prevents the formation of mature infectious viral particles.

• Effect: Produces non-infectious, immature HIV particles → stops viral replication.

• Benefit: Effective even in patients with resistance to other protease inhibitors.

2️⃣ Ritonavir

• Class: Protease Inhibitor (used as booster)

• Mechanism of Action:

  • At low doses, Ritonavir does not act as the main antiretroviral but inhibits CYP3A4 enzyme in the liver.

  • This boosts Darunavir plasma concentration, prolonging its action and improving antiviral efficacy.

• Effect: Enhances Darunavir’s activity, allowing once-daily dosing.

🩺 How To Take Danavir-R 800?

• Usually taken once daily with food.

• Must always be used in combination with other antiretroviral drugs.

• Do not skip doses – adherence is critical for preventing resistance.

🌟 Benefits Of Danavir-R 800

• ✔️ Potent HIV-1 viral suppression

• ✔️ Effective against resistant HIV strains

• ✔️ Boosted with Ritonavir → improved efficacy & duration

• ✔️ Slows disease progression and maintains immune function

⚠️ Possible Side Effects

• Common: Diarrhea, nausea, headache, abdominal pain, rash.

• Moderate: Elevated liver enzymes, high cholesterol, increased blood sugar.

• Serious (rare): Severe liver toxicity, pancreatitis, allergic reactions, redistribution of body fat (lipodystrophy).

🧾 Safety Advice

• 🚫 Not recommended in patients with severe liver impairment.

• ⚠️ Avoid use with strong CYP3A4 inducers (rifampin, St. John’s Wort, carbamazepine, phenytoin).

• ⚠️ Caution in patients with hemophilia (may increase bleeding risk).

• 🩺 Regular monitoring of liver function, cholesterol, and blood sugar is advised.

❓ FAQs

1. What is Danavir-R 800 used for?
➡️ For the treatment of HIV-1 infection, in combination with other antiretroviral drugs.

2. Does Danavir-R cure HIV?
➡️ No, it controls HIV but does not cure it. Lifelong therapy is needed.

3. Can Danavir-R be taken alone?
➡️ No, it must always be used with other antiretroviral medicines.

4. Why is Ritonavir included?
➡️ Ritonavir acts as a booster, improving Darunavir’s blood levels and effectiveness.

5. Can I drink alcohol while on Danavir-R?
➡️ Best avoided, as alcohol may increase liver strain.

🌍 Why Choose Medipills Pharma For Danavir-R 800?

• 💊 Trusted exporter of authentic HIV medicines.

• 🌟 WHO-GMP certified production.

• 📦 Secure global shipping.

• 🏥 Widely supplied to hospitals, NGOs & clinics.

• ✅ Affordable & reliable supply chain.